Platinum
Obtain all trophies

Isaac's Tears
Kill Isaac with Isaac

Mom's Knife
Kill Satan with Isaac

Isaac's Heart
Kill Isaac with The Lost

The Mind
Kill Satan with The Lost

Magdalene
Have 7 or more max red hearts at one time

The Relic
Kill Isaac with Maggy

Guardian Angel
Kill Satan with Maggy

Cain
Hold 55 or more pennies at one time

The Coin Bag
Kill Isaac with Cain

The Bomb Bag
Kill Satan with Cain

Judas
Kill Satan

The Guillotine
Kill Isaac with Judas

Judas' Tongue
Kill Satan with Judas

Eve
Beat 2 levels in a row without picking up any hearts

Eve's Bird Foot
Kill Isaac with Eve

The Razor
Kill Satan with Eve

Samson
Beat 2 levels in a row without taking damage

Bloody Lust
Kill Isaac with Samson

Blood Rights
Kill Satan with Samson

Azazel
Make 3 deals with the devil in one run

The Satanic Bible
Kill Isaac with Azazel

Daemon's Tail
Kill Satan with Azazel

Lazarus
Have 4 or more soul hearts at one time

Lazarus' Rags
Kill Isaac with Lazarus

Broken Ankh
Kill Satan with Lazarus

Eden
Beat the Womb for the first time

A Blank Card
Kill Isaac with Eden

The Book Of Secrets
Kill Satan with Eden

Something from the future
Beat the Basement 40 times

Something Cute
Beat the Caves 30 times

Something sticky
Beat the Depths 20 times

Basement Boy
Beat the Basement/Cellar without taking damage

Spelunker Boy
Beat the Caves/Catacombs without taking damage

Dark Boy
Beat the Depths/Necropolis without taking damage

Mama's Boy
Beat the Womb/Utero without taking damage

Dead Boy
Beat the Chest or Dark Room without taking damage

Challenges
Beat all 20 Challenges

Boss Rush
Beat the Boss Rush

Dark Room
Beat the Dark Room

The Chest
Beat the Chest

Lost Poster
Beat the Dark Room with Isaac

Little Baggy
Collect 2 of either Roid Rage, The Virus, Growth Hormones, Experimental Treatment, or Speed Ball

The Womb
Kill Mom

The Halo
Kill Mom using the Bible

Transcendence
Kill Mom's Heart 3 times

Everything Is Terrible
Kill Mom's Heart 5 times

A Quarter
Kill Mom's Heart 8 times

A Fetus In A Jar
Kill Mom's Heart 9 times

Blue Baby
Kill Mom's Heart 10 times

It Lives
Kill Mom's Heart 11 times

Forget Me Now
Kill Satan with ???

The Book Of Sin
Kill all 7 sins

The Polaroid
Beat Cathedral 5 times

The Negative
Beat Sheol 5 times

Golden God
You are the best!

Platinum God
Collect all items and unlock all secrets and endings

The Lost
Finish the game's final secret

Real Platinum God
100% the game